COMBINATION OF CRIZOTINIB AND OSIMERTINIB IN T790M+ EGFR-MUTANT NON-SMALL CELL LUNG CANCER WITH EMERGING MET AMPLIFICATION POST-OSIMERTINIB PROGRESSION IN A 10-YEAR SURVIVOR: A CASE REPORT

Tyrosine kinase inhibitors (TKIs) represent TRIPHLAX-750 the standard treatment for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.The duration of the response is, however, limited in time owing to the development of resistance mechanisms to both first- and second-generation agents such

Among emergent applications of digital watermarking are copyright protection and proof of ownership.Recently, Makbol and Khoo (2013) have proposed for these applications a new robust Skort blind image watermarking scheme based on the redundant discrete wavelet transform (RDWT) and the singular value decomposition (SVD).In this paper, we present two

In the present study the genetic variability of European sardine from Adriatic and Ionian seas was investigated in order to detect the occurrence of genetic structure within and between Skort these basins.In several samples the analysis of genetic variability at eight microsatellite loci showed a number of homozygote individuals higher than expecte

Consumption of ready-to-eat chopped fruits sold in the streets is a concern, as such activities are outside the regulation and protection in most developing countries.Ready-to-eat mangos are commonly sold as wedges in plastic cups at ambient temperature by mobile vendors in Ecuador, thus they are prone to contamination by bacteria, which poses a sa